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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ntv</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-технический вестник информационных технологий, механики и оптики</journal-title><trans-title-group xml:lang="en"><trans-title>Scientific and Technical Journal of Information Technologies, Mechanics and Optics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-1494</issn><issn pub-type="epub">2500-0373</issn><publisher><publisher-name>Университет ИТМО</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17586/2226-1494-2024-24-5-824-833</article-id><article-id custom-type="elpub" pub-id-type="custom">ntv-153</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КОМПЬЮТЕРНЫЕ СИСТЕМЫ И ИНФОРМАЦИОННЫЕ ТЕХНОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>COMPUTER SCIENCE</subject></subj-group></article-categories><title-group><article-title>Классификация поражений рассеянным склерозом посредством анализа изображений магнитно-резонансной томографии методом глубокого обучения</article-title><trans-title-group xml:lang="en"><trans-title>Classification of multiple sclerosis lesion through Deep Learning analysis of MRI images</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9960-8061</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дивья</surname><given-names>М.</given-names></name><name name-style="western" xml:lang="en"><surname>Divya</surname><given-names>M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дивья Матаван - PhD, исследователь</p><p>Кампус Рамапурам, Ченнаи, 600089</p></bio><bio xml:lang="en"><p>Mathavan Divya - PhD, Researcher</p><p>Ramapuram Campus, Chennai, 600089</p></bio><email xlink:type="simple">divyam1@srmist.edu.in</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2122-5076</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дхилипан</surname><given-names>Дж.</given-names></name><name name-style="western" xml:lang="en"><surname>Dhilipan</surname><given-names>J.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дхилипан Джаесилан - PhD, профессор, руководитель</p><p>Кампус Рамапурам, Ченнаи, 600089</p></bio><bio xml:lang="en"><p>Jayeseelan Dhilipan - PhD, Professor, Header</p><p>Ramapuram Campus, Chennai, 600089</p></bio><email xlink:type="simple">hod.mca.rmp@srmist.edu.in</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2093-900X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сараванан</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Saravanan</surname><given-names>A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сараванан Аппу - PhD, профессор</p><p>Кампус Рамапурам, Ченнаи, 600089</p></bio><bio xml:lang="en"><p>Appu Saravanan - PhD, Professor</p><p>Ramapuram Campus, Chennai</p></bio><email xlink:type="simple">dean.academic@srmrmp.edu.in</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт науки и технологий SRM</institution><country>Индия</country></aff><aff xml:lang="en"><institution>SRM Institute of Science and Technology</institution><country>India</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Инженерный колледж Иасвари</institution><country>Индия</country></aff><aff xml:lang="en"><institution>Easwari Engineering College</institution><country>India</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>14</day><month>12</month><year>2024</year></pub-date><volume>24</volume><issue>5</issue><fpage>824</fpage><lpage>833</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дивья М., Дхилипан Д., Сараванан А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Дивья М., Дхилипан Д., Сараванан А.</copyright-holder><copyright-holder xml:lang="en">Divya M., Dhilipan J., Saravanan A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ntv.elpub.ru/jour/article/view/153">https://ntv.elpub.ru/jour/article/view/153</self-uri><abstract><p>Рассеянный склероз (РС) представляет собой прогрессирующее аутоиммунное заболевание, поражающее центральную нервную систему. Раннее и точное обнаружение поражений РС на снимках магнитно-резонансной томографии (МРТ) головного мозга имеет решающее значение для эффективного лечения. В работе предлагается классификация на основе глубокого обучения для автоматического обнаружения и диагностики поражений РС на снимках МРТ, использующий сверточные нейронные сети (Convolutional Neural Network, CNNs) для точной идентификации и классификации поражений. Классификация включает в себя всесторонний анализ наборов данных МРТ и этапы их предварительной обработки, такие как нормализация и сегментация поражений. Предложенная архитектура CNN, разработанная для обнаружения поражений РС, достигает точности 98,2 % на тестовом наборе данных. Благодаря внедрению передовых методов распознавания изображений, представленный метод глубокого обучения классифицирует поражения РС среди различных патологий мозга, присутствующих на снимках МРТ. Метод выделяет поражения РС на снимках МРТ, помогая нейрорадиологам в точной диагностике и планировании лечения. Исследование вносит вклад в улучшение диагностики РС, предоставляя надежный и автоматизированный инструмент обнаружения и классификации поражений.</p></abstract><trans-abstract xml:lang="en"><p>Multiple Sclerosis (MS) is a progressive autoimmune disease affecting the central nervous system, causing communication disruptions between the brain and the body. Early and accurate detection of MS lesions in brain Magnetic Resonance Imaging (MRI) scans is crucial for effective treatment. This paper proposes MSNet, a deep learning-based approach for automatic detection and diagnosis of MS lesions from MRI images, leveraging Convolutional Neural Networks (CNNs) for precise lesion identification and classification. Our methodology involves a comprehensive analysis of MRI datasets, including preprocessing steps such as normalization and lesion segmentation. We propose a novel CNN architecture tailored for MS lesion detection, achieving an accuracy rate of 98.2 % on the test dataset. By incorporating advanced image recognition techniques, our system classifies MS lesions from diverse brain pathologies present in MRI images. The model also highlights MS lesions within the MRI images, aiding neuroradiologists in accurate diagnosis and treatment planning. This study contributes significantly to improving MS diagnosis by providing a reliable and automated tool for lesion detection and classification.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рассеянный склероз</kwd><kwd>машинное обучение</kwd><kwd>МРТ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>multiple sclerosis</kwd><kwd>machine learning</kwd><kwd>MRI</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">López-Dorado A., Pérez J., Rodrigo M.J., Miguel-Jiménez J.M., Ortiz M., de Santiago L., López-Guillén E., Blanco R., Cavalliere C., Morla E.M.S., Boquete L., Garcia-Martin E. Diagnosis of multiple sclerosis using multifocal ERG data feature fusion. Information Fusion, 2021, vol. 76, pp. 157–167. https://doi.org/10.1016/j.inffus.2021.05.006</mixed-citation><mixed-citation xml:lang="en">López-Dorado A., Pérez J., Rodrigo M.J., Miguel-Jiménez J.M., Ortiz M., de Santiago L., López-Guillén E., Blanco R., Cavalliere C., Morla E.M.S., Boquete L., Garcia-Martin E. Diagnosis of multiple sclerosis using multifocal ERG data feature fusion // Information Fusion. 2021. V. 76. P. 157–167. https://doi.org/10.1016/j.inffus.2021.05.006</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Mohseni E., Moghaddasi S.M. A hybrid approach for MS diagnosis through nonlinear EEG descriptors and metaheuristic optimized classification learning. Computational Intelligence and Neuroscience, 2022, vol. 2022, pp. 5430528. https://doi.org/10.1155/2022/5430528</mixed-citation><mixed-citation xml:lang="en">Mohseni E., Moghaddasi S.M. A hybrid approach for MS diagnosis through nonlinear EEG descriptors and metaheuristic optimized classification learning // Computational Intelligence and Neuroscience. 2022. V. 2022. P. 5430528. https://doi.org/10.1155/2022/5430528</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ahmadi A., Davoudi S., Daliri M.R. Computer Aided Diagnosis System for multiple sclerosis disease based on phase to amplitude coupling in covert visual attention. Computer Methods and Programs in Biomedicine, 2019, vol. 169, pp. 9–18. https://doi.org/10.1016/j.cmpb.2018.11.006</mixed-citation><mixed-citation xml:lang="en">Ahmadi A., Davoudi S., Daliri M.R. Computer Aided Diagnosis System for multiple sclerosis disease based on phase to amplitude coupling in covert visual attention // Computer Methods and Programs in Biomedicine. 2019. V. 169. P. 9–18. https://doi.org/10.1016/j.cmpb.2018.11.006</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Karaca B.K., Akşahin M.F., Öcal R. Detection of multiple sclerosis from photic stimulation EEG signals. Biomedical Signal Processing and Control, 2021, vol. 67, pp. 102571. https://doi.org/10.1016/j.bspc.2021.102571</mixed-citation><mixed-citation xml:lang="en">Karaca B.K., Akşahin M.F., Öcal R. Detection of multiple sclerosis from photic stimulation EEG signals // Biomedical Signal Processing and Control. 2021. V. 67. P. 102571. https://doi.org/10.1016/j.bspc.2021.102571</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">De Santiago L., Morla E.M.S., Ortiz M., López E., Usanos C.A., Alonso-Rodríguez M.C., Barea R., Cavaliere-Ballesta C., Fernández A., Boquete L. A computer-aided diagnosis of multiple sclerosis based on mfVEP recordings. PLoS ONE, 2019, vol. 14, no. 4, pp. e0214662. https://doi.org/10.1371/journal.pone.0214662</mixed-citation><mixed-citation xml:lang="en">De Santiago L., Morla E.M.S., Ortiz M., López E., Usanos C.A., Alonso-Rodríguez M.C., Barea R., Cavaliere-Ballesta C., Fernández A., Boquete L. A computer-aided diagnosis of multiple sclerosis based on mfVEP recordings // PLoS ONE. 2019. V. 14. N 4. P. e0214662. https://doi.org/10.1371/journal.pone.0214662</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Yperman J., Becker T., Valkenborg D., Popescu V., Hellings N., Van Wijmeersch B., Peeters L.M. Machine learning analysis of motor evoked potential time series to predict disability progression in multiple sclerosis. BMC Neurology, 2020, vol. 20, no. 1, pp. 105. https://doi.org/10.1186/s12883-020-01672-w</mixed-citation><mixed-citation xml:lang="en">Yperman J., Becker T., Valkenborg D., Popescu V., Hellings N., Van Wijmeersch B., Peeters L.M. Machine learning analysis of motor evoked potential time series to predict disability progression in multiple sclerosis // BMC Neurology. 2020. V. 20. N 1. P. 105. https:// doi.org/10.1186/s12883-020-01672-w</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Solana E., Martinez-Heras E., Casas-Roma J., Calvet L., Lopez-Soley E., Sepulveda M., Sola-Valls N., Montejo C., Blanco Y., Pulido-Valdeolivas I., Andorra M., Saiz A., Prados F., Llufriu S. Modified connectivity of vulnerable brain nodes in multiple sclerosis, their impact on cognition and their discriminative value. Scientific Reports, 2019, vol. 9, pp. 20172. https://doi.org/10.1038/s41598-019-56806-z</mixed-citation><mixed-citation xml:lang="en">Solana E., Martinez-Heras E., Casas-Roma J., Calvet L., Lopez-Soley E., Sepulveda M., Sola-Valls N., Montejo C., Blanco Y., PulidoValdeolivas I., Andorra M., Saiz A., Prados F., Llufriu S. Modified connectivity of vulnerable brain nodes in multiple sclerosis, their impact on cognition and their discriminative value // Scientific Reports. 2019. V. 9. P. 20172. https://doi.org/10.1038/s41598-019-56806-z</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kawahara J. Spinal Cord Segmentation and Disability Prediction in Multiple Sclerosis Using Novel Optimization and Machine Learning Methods: Ph.D. Dissertation. Vancouver Island University, Nanaimo, BC, Canada. 2013, 57 p.</mixed-citation><mixed-citation xml:lang="en">Kawahara J. Spinal Cord Segmentation and Disability Prediction in Multiple Sclerosis Using Novel Optimization and Machine Learning Methods: Ph.D. Dissertation. Vancouver Island University, Nanaimo, BC, Canada. 2013. 57 p.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang H., Alberts E., Pongratz V., Mühlau M., Zimmer C., Wiestler B., Eichinger P. Predicting conversion from clinically isolated syndrome to multiple sclerosis–An imaging-based machine learning approach. NeuroImage Clinical, 2019, vol. 21, pp. 101593. https://doi.org/10.1016/j.nicl.2018.11.003</mixed-citation><mixed-citation xml:lang="en">Zhang H., Alberts E., Pongratz V., Mühlau M., Zimmer C., Wiestler B., Eichinger P. Predicting conversion from clinically isolated syndrome to multiple sclerosis–An imaging-based machine learning approach // NeuroImage Clinical. 2019. V. 21. P. 101593. https://doi.org/10.1016/j.nicl.2018.11.003</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Rezaee A., Rezaee K., Haddadnia J., Gorji H.T. Supervised metaheuristic extreme learning machine for multiple sclerosis detection based on multiple feature descriptors in MR images. SN Applied Sciences, 2020, vol. 2, no. 5, pp. 866. https://doi.org/10.1007/s42452-020-2699-y</mixed-citation><mixed-citation xml:lang="en">Rezaee A., Rezaee K., Haddadnia J., Gorji H.T. Supervised metaheuristic extreme learning machine for multiple sclerosis detection based on multiple feature descriptors in MR images // SN Applied Sciences. 2020. V. 2. N 5. P. 866. https://doi.org/10.1007/s42452-020-2699-y</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ekşi Z., Özcan E.M., Çakıroğlu M., Öz C., Aralaşmak A. Differentiation of multiple sclerosis lesions and low-grade brain tumors on MRS data: Machine learning approaches. Neurological Sciences, 2021, vol. 42, no. 8, pp. 3389–3395. https://doi.org/10.1007/s10072-020-04950-0</mixed-citation><mixed-citation xml:lang="en">Ekşi Z., Özcan E.M., Çakıroğlu M., Öz C., Aralaşmak A. Differentiation of multiple sclerosis lesions and low-grade brain tumors on MRS data: Machine learning approaches // Neurological Sciences. 2021. V. 42. N 8. P. 3389–3395. https://doi.org/10.1007/s10072-020-04950-0</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Peng Y., Zheng Y., Tan Z., Liu J., Xiang Y., Liu H., Dai L., Xie Y., Wang J., Zeng C., Li Y. Prediction of unenhanced lesion evolution in multiple sclerosis using radiomics-based models: A machine learning approach. Multiple Sclerosis and Related Disorders, 2021, vol. 53, pp. 102989. https://doi.org/10.1016/j.msard.2021.102989</mixed-citation><mixed-citation xml:lang="en">Peng Y., Zheng Y., Tan Z., Liu J., Xiang Y., Liu H., Dai L., Xie Y., Wang J., Zeng C., Li Y. Prediction of unenhanced lesion evolution in multiple sclerosis using radiomics-based models: A machine learning approach // Multiple Sclerosis and Related Disorders. 2021. V. 53. P. 102989. https://doi.org/10.1016/j.msard.2021.102989</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Eshaghi A., Young A.L., Wijeratne P.A., Prados F., Arnold D.L., Narayanan S., Guttmann C.R.G., Barkhof F., Alexander D.C., Thompson A.J., Chard D., Ciccarelli O. Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data. Nature Communications, 2021, vol. 12, no. 1, pp. 2078. https://doi.org/10.1038/s41467-021-22265-2</mixed-citation><mixed-citation xml:lang="en">Eshaghi A., Young A.L., Wijeratne P.A., Prados F., Arnold D.L., Narayanan S., Guttmann C.R.G., Barkhof F., Alexander D.C., Thompson A.J., Chard D., Ciccarelli O. Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data // Nature Communications. 2021. V. 12. N 1. P. 2078. https://doi.org/10.1038/s41467-021-22265-2</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Bonanno L., Mammone N., De Salvo S., Bramanti A., Rifici C., Sessa E., Bramanti P., Marino S., Ciurleo R. Multiple Sclerosis lesions detection by a hybrid Watershed-Clustering algorithm. Clinical Imaging, 2021, vol. 72, pp. 162–167. https://doi.org/10.1016/j.clinimag.2020.11.006</mixed-citation><mixed-citation xml:lang="en">Bonanno L., Mammone N., De Salvo S., Bramanti A., Rifici C., Sessa E., Bramanti P., Marino S., Ciurleo R. Multiple Sclerosis lesions detection by a hybrid Watershed-Clustering algorithm // Clinical Imaging. 2021. V. 72. P. 162–167. https://doi.org/10.1016/j.clinimag.2020.11.006</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Iswisi A.F.A., Karan O., Rahebi J. Diagnosis of Multiple Sclerosis Disease in Brain Magnetic Resonance Imaging Based on the Harris Hawks Optimization Algorithm. BioMed Research International, 2021, pp. 3248834. https://doi.org/10.1155/2021/3248834</mixed-citation><mixed-citation xml:lang="en">Iswisi A.F.A., Karan O., Rahebi J. Diagnosis of Multiple Sclerosis Disease in Brain Magnetic Resonance Imaging Based on the Harris Hawks Optimization Algorithm // BioMed Research International. 2021. P. 3248834. https://doi.org/10.1155/2021/3248834</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Jain S., Rajpal N., Yadav J. Supervised and unsupervised machine learning techniques for multiple sclerosis identification: A performance comparative analysis. Advances in Intelligent Systems and Computing, 2022, vol. 1374, pp. 369–381. https://doi.org/10.1007/978-981-16-3346-1_30</mixed-citation><mixed-citation xml:lang="en">Jain S., Rajpal N., Yadav J. Supervised and unsupervised machine learning techniques for multiple sclerosis identification: A performance comparative analysis // Advances in Intelligent Systems and Computing. 2022. V. 1374. P. 369–381. https://doi.org/10.1007/978-981-16-3346-1_30</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia-Martin E., Ortiz M., Boquete L., Sánchez-Morla E.M., Barea R., Cavaliere C., Vilades E., Orduna E., Rodrigo M.J. Early diagnosis of multiple sclerosis by OCT analysis using Cohen’s d method and a neural network as classifier. Computers in Biology and Medicine, 2021, vol. 129, pp. 104165. https://doi.org/10.1016/j.compbiomed.2020.104165</mixed-citation><mixed-citation xml:lang="en">Garcia-Martin E., Ortiz M., Boquete L., Sánchez-Morla E.M., Barea R., Cavaliere C., Vilades E., Orduna E., Rodrigo M.J. Early diagnosis of multiple sclerosis by OCT analysis using Cohen’s d method and a neural network as classifier // Computers in Biology and Medicine. 2021. V. 129. P. 104165. https://doi.org/10.1016/j.compbiomed.2020.104165</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Montolío A., Cegoñino J., Garcia-Martin E., Pérez del Palomar A. Comparison of machine learning methods using spectralis OCT for diagnosis and disability progression prognosis in multiple sclerosis. Annals of Biomedical Engineering, 2022, vol. 50, no. 5, pp. 507–528. https://doi.org/10.1007/s10439-022-02930-3</mixed-citation><mixed-citation xml:lang="en">Montolío A., Cegoñino J., Garcia-Martin E., Pérez del Palomar A. Comparison of machine learning methods using spectralis OCT for diagnosis and disability progression prognosis in multiple sclerosis // Annals of Biomedical Engineering. 2022. V. 50. N 5. P. 507–528. https://doi.org/10.1007/s10439-022-02930-3</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
